jwh 018 powder for sale online in USA.We present in some varieties of the herbal concoction “Spice.” This synthetic cannabinoid is primarily use illegally due to its intoxicating properties, which resemble those of cannabis’ 9-THC. jwh 018 is far more powerful than comparable doses of cannabis, but it also poses major obstacles to identification using standard 9-THC testing tests. JWH-018 was added to the US Drug Enforcement Agency’s (DEA) list of Drugs and Chemicals of Concern in July 2009. Several states, including Alabama, Arkansas, and Florida, have implemented laws limiting the sale of or possession of jwh 018 powder in addition to reports of Spice seizures in Ohio and Florida.

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JWH 018, synthesized from the aminoalkylindole WIN 55,212-2, is a slightly selective agonist of the peripheral cannabinoid (CB2) receptor. For a CB1:CB2 ratio of 3.061, the Ki values for binding to the central cannabinoid (CB1) and CB2 receptors are 9.0 and 2.94 nM, respectively. When evaluated in rats, it had effects similar to those of WIN 55,212-2 on the inhibition of spontaneous activity, maximum antinociceptive effect in the tail-flick experiment, and rectal temperature.jwh 018 powder for sale online in USA

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Animal pharmacology tests reveal that 018 pill exhibits 9-THC-like action. It causes analgesia, lowers body temperature, causes catalepsy, and decreases general activity in mice. Scientists can forecast psychoactivity in people similar to that of 9-THC using these four effects taken together. The activity of JWH-018 in all four tests indicates that it is likely to produce psychoactive effects similar to those of THC in humans. JWH-018 generalized to 9-THC in trials on drug discrimination in rats, producing subjective effects that were comparable to those of 9-THC. JWH-018 exhibits agonist qualities in functional assays and binds to the brain cannabinoid receptor CB1 with enhanced affinity compared to 9-THC, indicating that it would have the same effects as 9-THC in vivo.